Factors that predispose to HPA axis suppression include the use of high-potency corticosteroids, large treatment surface areas, prolonged use, use of occlusive dressings, altered skin barrier, liver failure, and young age.Įvaluation for HPA axis suppression may be done by using the adrenocorticotropic hormone (ACTH) stimulation test. This may occur during or after withdrawal of treatment. (5.1, 8.4)ĥ.1 Hypothalamic-Pituitary-Adrenal (HPA) Axis Suppression and Other Unwanted Systemic Glucocorticoid EffectsĬronolevel (Betamethasone Dipropionate) Spray can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency. Pediatric patients may be more susceptible to systemic toxicity when treated with topical corticosteroids.High potency corticosteroids, large treatment surface areas, prolonged use, use of occlusive dressings, altered skin barrier, liver failure and young age may predispose patients to HPA axis suppression.Modify use if HPA axis suppression develops.Use of topical corticosteroids may require periodic evaluation for HPA axis suppression.Cushing's syndrome, hyperglycemia, and unmasking of latent diabetes mellitus can result from systemic absorption of topical corticosteroids.Cronolevel Spray can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency during or after treatment.Spray: 0.05% (equivalent to 0.5 mg betamethasone/g) (3) Each gram of Cronolevel (Betamethasone Dipropionate) Spray contains 0.643 mg Cronolevel (Betamethasone Dipropionate) USP (equivalent to 0.5 mg betamethasone) in a slightly thickened, white to off-white oil-in-water emulsion. Not for oral, ophthalmic, or intravaginal use.Avoid use on the face, scalp, axilla, groin, or other intertriginous areas.Do not use with occlusive dressings unless directed by a physician.Do not use if atrophy is present at the treatment site.
Treatment beyond 4 weeks is not recommended.ĭiscontinue Cronolevel (Betamethasone Dipropionate) Spray when control is achieved.ĭo not use if atrophy is present at the treatment site.ĭo not bandage, cover, or wrap the treated skin area unless directed by a physician.Īvoid use on the face, scalp, axilla, groin, or other intertriginous areas.Ĭronolevel (Betamethasone Dipropionate) Spray is for topical use only. Use Cronolevel (Betamethasone Dipropionate) Spray for up to 4 weeks of treatment. (1)Īpply Cronolevel (Betamethasone Dipropionate) Spray to the affected skin areas twice daily and rub in gently. Cronolevel (Betamethasone Dipropionate) Spray is indicated for the treatment of mild to moderate plaque psoriasis in patients 18 years of age or older.Ĭronolevel (Betamethasone Dipropionate) Spray is a corticosteroid indicated for the treatment of mild to moderate plaque psoriasis in patients 18 years of age or older.